Two of the most powerful hydrators in modern skincare are polyglutamic acid (PGA) and hyaluronic acid (HA). While both lock in moisture, they work in different ways. Here is a head-to-head comparison to help you choose.
What is polyglutamic acid?
- A natural, biodegradable polymer made from glutamic acid
- Can hold up to 4,000–5,000 times its weight in water
- Often derived from fermented soybeans
PGA vs HA: key differences
1. Hydration capacity
- PGA retains more water per molecule than HA
- HA is larger and forms a surface moisture film
2. Humectant mechanism
- PGA blocks hyaluronidase, slowing HA breakdown
- HA directly binds and holds water in the skin
3. Barrier and anti-wrinkle support
- PGA helps smooth the skin barrier and reduce fine lines
- HA plumps and improves skin texture
Which one should you choose?
The strongest formulas combine both: HA for immediate plumping and PGA for prolonged, superior moisture retention. Together they deliver deep, long-lasting hydration suitable for all skin types.
For formulators, blending high-purity PGA with HA creates a standout, high-performance moisturising serum or cream.
